Protein Stability Analysis Market

Protein Stability Analysis Market is Reshaping Biologics Development Trends by Advancements in Instrumentation


The protein stability analysis market comprises instruments and consumables used to analyze the stability and integrity of protein therapeutics. Instruments such as differential scanning calorimeters, spectroscopic instruments, and chromatography systems are widely employed during preformulation and formulation development stages to select optimum buffer conditions, identify degradation pathways, screen for stabilizers, and validate shipping/storage conditions. The rising demand for biologics and growing adoption of combination products containing proteins and peptides are propelling the need for tools to characterize protein stability.

The Global Protein Stability Analysis Market is estimated to be valued at US$ 2.43 BN in 2024 and is expected to exhibit a CAGR of 11% over the forecast period 2024 to 2031.

Key Takeaways

Key players operating in the Protein Stability Analysis Market Demand are Thermo Fisher Scientific, Inc., Enzo Biochem, Inc., PerkinElmer Inc., NanoTemper, GE Healthcare, HORIBA, Ltd., Malvern Panalytical Ltd., Agilent Technologies, Inc., SETARAM Instrumentation, Unchained Labs, Waters Corporation, and Applied Photophysics Ltd. The increasing demand for protein-based drugs and rising pharmaceutical R&D spending are major factors driving the growth of the protein stability analysis market. Growing pressure to minimize impurities and extend product shelf-life have compelled biopharmaceutical companies to adopt sophisticated stability testing techniques. Moreover, the market is witnessing rapid expansion in the Asia Pacific region owing to setting up of new biologics manufacturing facilities and rising generics market in nations such as China, India, and South Korea.

Market key trends

One of the key trends gaining traction in the protein stability analysis market is the development of microfluidic-based solutions. Miniaturized microfluidic platforms are enabling high-throughput screening of stability-indicating formulation variables. By integrating various analytical techniques on a single chip-based device, microfluidics allow significant reduction in sample/reagent volume requirements and analysis time. For instance, Angoss offers a microfluidic-based platform STAN that characterizes protein stability using differential scanning calorimetry and spectroscopy for as low as 100 micrograms of sample. Such innovations are expected to transform stability testing workflows in the coming years.

Porter’s Analysis

Threat of new entrants: New companies entering the protein stability analysis market face high costs for R&D, manufacturing facilities and distribution networks.

Bargaining power of buyers: Individual customers have low bargaining power in this consolidate market where a few key players dominate the market.

Bargaining power of suppliers: Presence of multiple equipment and reagent suppliers reduces bargaining power of each individual supplier in the protein stability analysis market.

Threat of new substitutes: No close substitutes exist for protein stability analysis techniques used in drug discovery and development.

Competitive rivalry: Major players compete based on innovation, reliability and price of their protein stability analysis offerings.

Geographical Regions

North America dominates the protein stability analysis market in terms of value largely due to presence of well-established biopharmaceutical industry and favorable government policies for life sciences research.

Asia Pacific region is expected to witness fastest growth during forecast period driven by increasing R&D investments from generic drugs manufacturers based in India and China coupled with expansion of clinical research organizations in the region.

1.  Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it