Phosphoramidite Market

The Global Phosphoramidite Market is poised for Significant Growth driven by DNA sequencing trends by 2024


The global phosphoramidite market comprises of phosphoramidite reagents that are used as synthetic intermediates in the solid-phase synthesis of DNA and RNA. Phosphoramidites help in protecting the DNA and RNA from degradation and oxidation during the chemical synthesis process. They are useful in molecular biology applications such as DNA sequencing, DNA cloning, site-directed mutagenesis and polymerase chain reaction. The increasing demand for DNA sequencing and synthesis is driving the growth of the phosphoramidite market.

The Global Phosphoramidite Market is estimated to be valued at US$ 1,011.3 MN in 2024 and is expected to exhibit a CAGR of 7.3% over the forecast period 2024 to 2031.

The Phosphoramidite Market Demand is witnessing strong growth due to the rising applications of DNA sequencing techniques in various areas such as personalized medicine, molecular diagnostics and forensic science. Phosphoramidites help improve efficiency and accuracy in DNA sequencing by protecting the molecules during synthesis.

Key Takeaways

Key players: Key players operating in the phosphoramidite market are Glen Research, ChemGenes Corporation, Link Technologies Ltd., BioAutomation Corporation, Merck KGaA, Sigma-Aldrich (now part of MilliporeSigma, a Merck Group company), LGC Biosearch Technologies, Thermo Fisher Scientific, Biosynthesis Inc., ATDBio Ltd., Genscript Biotech Corporation, Expedeon AG, Wuxi Donglin Sci & Tech Development Co., Ltd., Bio-Synthesis Inc., and ChemGenes Corporation.

Growing demand: The demand for phosphoramidite reagents is growing significantly with the increasing popularity of DNA sequencing techniques. Next generation sequencing has created huge opportunities for synthetic biology and DNA synthesis. Various players are focusing on expanding their production capacities to meet the rising demand from biotechnology and pharmaceutical companies.

Global expansion: Leading players in the phosphoramidite market are engaging in mergers and acquisitions to strengthen their market position. They are also expanding their geographic footprints in high growth regions like Asia Pacific and Latin America. New product launches catering to customized needs and establishment of production and distribution networks globally are helping companies achieve global expansion.

Market key trends
The key trends in the global phosphoramidite market include increasing investments in DNA sequencing projects, introduction of new phosphoramidite formulations and automation of DNA synthesis process. Next generation sequencing has gained immense popularity for DNA sequencing of entire genomes. Various governments and private organizations are funding large scale genome sequencing projects which is driving the need for phosphoramidite reagents. Further, industry players are developing phosphoramidites blended with novel protecting groups to enhance characteristics like stability and yield. Automation of DNA synthesizers using phosphoramidites is another trend, helping achieve higher throughput and reproducibility. This is expected to propel the market growth over the forecast period.

Porter’s Analysis
Threat of new entrants: High capital requirements and economies of scale in production pose barrier for new firms entering the market.
Bargaining power of buyers: Purchasers have moderate bargaining power as there exists several product alternatives available from different suppliers.
Bargaining power of suppliers: Suppliers have moderate bargaining power due to availability of substitute raw materials. Suppliers may also form collaborative agreements.
Threat of new substitutes: Threat of substitution is moderate as few alternative technologies are available that can perform similar chemical synthesis, though phosphoramidites are preferred for many DNA/RNA applications.
Competitive rivalry: The market is moderately concentrated with major players holding sizeable market share. Competition is based on quality, cost, and innovation.

Geographical regions where market value is concentrated:
North America region currently holds the largest share of the global phosphoramidite market, followed by Europe. Factors such as growing pharmaceutical industry, increasing R&D funding, rising demand for synthesized oligonucleotides from academic research organizations and biotech companies drive the market growth in these regions.

Fastest growing geographical region:
Asia Pacific region is expected to grow at the fastest rate during the forecast period. This is attributed to favorable government policies supporting life sciences sector, increasing investments by market players, rising consumer healthcare expenditure, growing number of pharmaceutical and biotechnology companies in emerging economies such as India and China.

1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it