Organ on a chip is a microfluidic cell culture device which aims to replicate human physiology and pathology. It helps to study tissue and organ level interactions in a controlled environment which is useful in drug development and toxicity testing.
Technological advancements in developing organs on chip is a major driverfueling growth of the market. For instance, researchers at the University of California, San Diego developed an artificial small intestine using microengineering whichaims to replicate key aspects of small intestinal tissue physiology. It consists of human intestinal epithelial cells cultured in microfluidic channels lined by porous membranes. The device closely mimics the tissue-tissue interfaces and peristalsis-like motions of the human small intestine. In addition, rising adoption of organ on a chip technology by pharmaceutical companies for drug screening and development is also propelling growth of the organ on a chip market. For example, companies likeEmulate and cnBio are using organ chipsto accelerate drug development by replicating human biology and physiology.
Organ On A Chip Market Drivers
Increasing Investment in Drug Discovery and Development”. Due to high failure rates and costs involved in clinical trials, many pharmaceutical companies are investing in developing lab grown organ models as an alternative to animal testing. Organ on chip models help identify potential drug toxicity and efficacy at a very early stage thus reducing costs associated with late stage drug failures.
Advancements in Microfluidics and Tissue Engineering”. Significant progress has been made in developing microfabrication techniques, 3D cell culture methods and microfluidic organ chip platforms. These advancements allow replication of complex human organ level structures and physiologies on a microchip with integrated functionality. Researchers are better able to mimic human disease conditions and response to drug candidates using these advanced organ chip technologies.
Organ On A Chip Market Restrain
High Development Costs”. Designing and fabricating organ chip microchips requires extensive multidisciplinary expertise. Obtaining primary human cells, developing multi-layer microfluidic organ structures and integrating various organ functionalities on a single microfluidic chip is a complex process which demands significant initial investments. This acts as a restraint for small companies and startups to enter this market.
Organ On A Chip Market Opportunity
Personalized Medicine”. Organ chips allow development of patient-specific disease models using cells obtained from individual patients. These personalized organ chip models can be used to identify most effective therapies tailored to a patient’s unique genetic profile. This presents a major opportunity for organ chip technologies to transform drug discovery and development towards a more personalized medicine approach.
Organ On A Chip Market Trends
Multi-Organ Interaction Models”. Current research focus is on developing advanced multi-organ chips where different organ chips can be linked to mimic inter-organ communication within the human body. These multi-organ chips will provide a more holistic understanding of how drugs or disease conditions may affect the complex interactions between different organs and systems in the body. This reflects the growing market trend towards developingdisease models with greater complexity and physiological relevance.
1. Source: Coherent Market Insights, Public sources, Desk research
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