Gene Synthesis Market is Estimated to Witness High Growth Owing to Rising Demand for Custom Gene Sequences


Gene Synthesis involves chemically producing DNA strands through solid-phase synthesis by assembling short oligonucleotides to attain the desired genetic code. It has applications in various end-use industries such as pharmaceutical and biotechnology.

Market Dynamics:

The Gene Synthesis Market is expected to witness significant growth over the forecast period owing to rising demand for customized gene sequences from pharmaceutical and biotechnology companies. Gene synthesis finds widespread application in developing novel therapeutics and genetically engineered crop technologies. Additionally, advancements in gene editing techniques such as CRISPR have further enabled researchers to easily modify genome sequences, thereby propelling demand for synthetic genes. Rapidly declining cost of gene synthesis technology is also expected to contribute to market growth during the forecast period.

Gene Synthesis Market Drivers:

Advancement in DNA Sequencing Technologies Is Driving the Growth of Gene Synthesis Market

Next generation DNA sequencing technologies are enabling scientists to sequence genomes at a much faster rate and lower costs than before. This is generating a massive amount of genomic data that needs to be analyzed. Gene synthesis allows researchers to order specific genes and genome fragments of interest for research applications such as functional genomics and molecular biology studies. The reduction in DNA sequencing costs is fueling more genomic research which is directly increasing the demand for gene synthesis services.

Increasing Application of Synthetic Genes in Disease Modeling and Drug Discovery

Synthetic genes find widespread application in developing disease models for researching new therapies. Scientists employ gene synthesis to generate mutations associated with diseases and study their impact at a molecular level. Pharmaceutical companies extensively utilize custom-designed genes to screen potential drug candidates and analyze drug-target interactions. As research into complex diseases intensifies and drug discovery undergoes further innovation, the use of synthetic genes will continue to rise substantially.

Gene Synthesis Market Restrains:

Intellectual Property Issues Pose Significant Challenges

Gene sequences synthesized contain substantial intellectual property that must be carefully regulated to avoid encroachment of commercial rights. Given the vast biological research data being generated daily, it is difficult to determine ownership and patent status of all sequences arising out of synthetic gene projects. Conflicts regarding IP issues tend to hinder scientific progress and collaboration between researchers. Resolving intellectual property concerns related to synthetic genes remains a complex problem for the industry.

Gene Synthesis Market Opportunity:

Emergence of Next Generation Gene Editing Techniques Creates New Avenues

Continuous advancements are being made in gene editing technologies such as CRISPR-Cas9 system that have revolutionized biomedical research. Novel gene editing tools enable highly targeted and precise genome engineering applications at lower costs. Emergence of “prime editing” that can insert, delete or modify single DNA letters without making double-strand breaks opens up therapeutic applications that were not feasible before. Transition to newer gene editing modalities will generate demand for customized genes and drive the synthetic biology market towards discovery, development and production of cell and gene therapies.

Gene Synthesis Market Trends:

Growth of Synbio Startups and Establishment of Genome Foundries

Venture capital interest in synthetic biology has been growing rapidly, with billions being invested into related startups annually. Emergence of several institutional genome foundries and commercial synthesis players points to the maturing of the industry. Factors such as outsourcing of genomic services, push for open science through development of standard biological parts will likely see more industrial consortiums and research partnerships coming up. Mainstreaming synthetic biology is expected to transform healthcare, agriculture and manufacturing sectors leading to profound commercial and societal impact in the long run.

1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it