Adoptive cell transfer therapy using tumor-infiltrating lymphocytes (TIL) refers to the extraction of immune cells from a patient’s own tumor, amplification and proliferation of these cells to generate vast numbers and then re-infusing these TIL back into the patient to elicit an anti-tumor immune response. It has been found to be an effective treatment against metastatic melanoma and other solid tumors. TIL therapy provides a personalized treatment approach that harnesses the patient’s own immune system to fight cancer.
The Global TIL Therapy Market is estimated to be valued at US$ 0.087 Bn in 2024 and is expected to exhibit a CAGR of 78.% over the forecast period 2024-2031.
Key Takeaways
Key players operating in the Global TIL Therapy market are Iovance Biotherapeutics, Instil Bio, Obsidian Therapeutics, Cellectis. Iovance Biotherapeutics is a clinical-stage biotechnology company focused on developing tumor-infiltrating lymphocyte (TIL) therapy for metastatic melanoma and other solid tumors. Instil Bio is a clinical-stage biopharmaceutical company developing tumor infiltrating lymphocyte therapies for patients with solid tumors.
The key opportunities in the Global TIL Therapy market include expanding approvals for TIL therapy in other cancer indications beyond melanoma and new drug candidates in clinical trials. Several biotechs are conducting clinical trials evaluating TIL therapy in cancers like non-small cell lung cancer, head and neck cancers, and urothelial carcinoma which can potentially drive the market growth. Advancements in cell manufacturing and sensitization techniques are helping increase the efficacy and consistency of TIL therapy. The development of Gene-Engineered T-Cell Receptors is enhancing the therapeutic properties of TILs.
Market Drivers
High unmet medical need in advanced cancers is one of the key drivers for the Global TIL Therapy Market. TIL therapy offers a novel treatment approach with curative potential and durable responses seen in metastatic melanoma patients which is driving its adoption. The approval of Tecartus and Yescarta, the first CAR T-cell therapies, established the potential of cell-based immunotherapies, increasing investor interest in TIL therapy developers. Increased research funding from govt. and private bodies to develop new adoptive cell transfer therapies is also fueling the market growth.
Current Challenges In The Global TIL Therapy Market:
The global TIL therapy market continues to face several challenges that are hampering its growth potential. High costs involved in the manufacturing and development of TIL therapy is a major concern. The process of extracting TILs from a patient’s tumor, expanding them in the laboratory, and infusing back to the patient requires specialized facilities and trained professionals which increases the treatment costs. Furthermore, the success rate of TIL therapy is still being evaluated and more research is needed to improve patient responses and durability of responses. The long process makes it difficult to bring TIL therapy to a large patient population. Additionally, the need for customized and personalized treatment for each patient increases the complexity of treatment administration.
SWOT Analysis
Strength: TIL therapy is a promising individualized immunotherapy approach with durable responses seen in some cancer types. It harnesses the patient’s own immune cells making it a non-invasive treatment option.
Weakness: The complex multi-step process of developing TIL therapy increases costs and hampers large scale commercialization. Currently only a few hospitals have expertise to offer this highly customized treatment.
Opportunity: With ongoing research, efficacies can be improved, costs lowered, and more solid tumor indications can be targeted. Streamlining the process and making it more standardized presents commercial opportunities.
Threats: Given the current challenges, other immune therapies like CAR T-cell therapy may emerge as dominant alternatives unless large clinical evidence establishes TIL therapy’s benefits in the coming years.
Geographical regions with largest market share currently include North America and Europe due to higher adoption of advanced cancer therapies. The United States holds the major market share currently owing to presence of key market players and ongoing clinical research for TIL therapy. However, Asia Pacific region is expected to witness highest growth during the forecast period driven by increasing healthcare investment and patient awareness in countries like China, Japan, and India.
In terms of growth, Asia Pacific region holds promising potential for TIL therapy market. The countries in Asia Pacific are making major investments in development of healthcare infrastructure and cancer treatment capabilities. Rising healthcare expenditure, increasing cancer incidence, and growing adoption of innovative immunotherapies are the key factors expected to drive higher demand for TIL therapy in Asia Pacific region during the forecast period.
What Are The Key Data Covered In This Global TIL Therapy Market Report?
:- Market CAGR throughout the predicted period
:- Comprehensive information on the aspects that will drive the Global TIL Therapy Market’s growth between 2024 and 2031.
:- Accurate calculation of the size of the Global TIL Therapy Market and its contribution to the market, with emphasis on the parent market
:- Realistic forecasts of future trends and changes in consumer behaviour
:- Global TIL Therapy Market Industry Growth in North America, APAC, Europe, South America, the Middle East, and Africa
:- A complete examination of the market’s competitive landscape, as well as extensive information on vendors
:- Detailed examination of the factors that will impede the expansion of Global TIL Therapy Market vendors
FAQ’s
Q.1 What are the main factors influencing the Global TIL Therapy Market?
Q.2 Which companies are the major sources in this industry?
Q.3 What are the market’s opportunities, risks, and general structure?
Q.4 Which of the top Global TIL Therapy Market companies compare in terms of sales, revenue, and prices?
Q.5 Which businesses serve as the Global TIL Therapy Market’s distributors, traders, and dealers?
Q.6 How are market types and applications and deals, revenue, and value explored?
Q.7 What does a business area’s assessment of agreements, income, and value implicate?
*Note:
1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it
About Author – Vaagisha Singh
Vaagisha brings over three years of expertise as a content editor in the market research domain. Originally a creative writer, she discovered her passion for editing, combining her flair for writing with a meticulous eye for detail. Her ability to craft and refine compelling content makes her an invaluable asset in delivering polished and engaging write-ups. LinkedIn